Science-informed
daily rituals

designed to fit real life

I was tired of the extremes. In my early 20s, hormonal breakouts, weight fluctuations, and an out-of-rhythm cycle left me choosing between prescriptions or restrictive wellness routines that never got to the root. With nearly a decade at Mayo Clinic and five years in clinical research, I did what I know best: I followed the evidence.

That’s how I found ingredients like myo-inositol + d-chiro-inositol in the clinically studied 40:1 ratio, found naturally in fruits and vegetables. This led to a breakthrough: I realized countless women were navigating the same symptoms without real support. Avvi was born from that gap – science-informed daily rituals designed to fit into real life and help restore your rhythm.

BUILT FROM lived experience

“I spent years thinking that waking up exhausted, wired, and off is just part of life. But clinical research told me that our bodies haven’t caught up to the pace of the world we live in. That’s why we built Avvi – to help fill the gaps real life creates, supporting the overnight window when your body finally has the space to recover, reset, and begin again.”

ZOE PERNA • FOUNDER, AVVI

Treating symptoms

at the source

Hormones respond to cortisol, sleep, and blood sugar. When something feels off — the irregular cycles, the wired-but-exhausted mornings — it’s rarely one thing. It’s a network under pressure. Avvi was built to support that network. One nightly ritual, formulated around the systems that actually drive how women feel. Not a stack of six bottles. Not a single-target claim. A formula designed for the hours your body does its most important work.

THE SCIENCE BEHIND THE TIMING

Your body does its most important work

at night

Between 10 pm and 2 am, cortisol hits its daily low, growth hormones peak, and your nervous system shifts into repair. It’s the window when hormonal recalibration happens and you get the right support.

Most supplements are built for morning. Unwind is built for this window. Inositols support hormone signaling and insulin sensitivity overnight. Magnesium, L-theanine, GABA, and taurine help your nervous system genuinely downshift. And, we take out the melatonin; because your body already knows what to do.

how we work

FOUR THINGS WE WON’T compromise on

WHOLE-SYSTEM
thinking

Hormone rhythm is a direct result of stress, sleep, and metabolism.
We formulate for the network.

DOSES THAT MATCH
the data

We use clinically studied ratios and forms, including the researched 40:1 inositol ratio. Because the right ingredient at the wrong dose
isn’t doing much.

NIGHTTIME,
because that's when it counts

The overnight repair window is real, researched, and underserved. We built Unwind to meet the body when it’s biologically ready for support.

A ritual
worth keeping

The most effective supplement is the one you actually take. Mixed berry flavored and monk fruit sweetened, it dissolves in seconds. Easy enough to do every night. Consistent enough to work.