THE RESEARCH INDEX
EIGHT SYSTEMS,
one nightly ritual01 • HORMONES
Hormone Balance Support
Hormone balance is a network of metabolic signaling, reproductive pathways, and stress response, all working together. The strongest human evidence behind this claim starts with inositols.
A large meta-analysis of randomized controlled trials found that myo-inositol significantly improved key hormonal and metabolic markers in women, including fasting insulin, insulin resistance, triglycerides, and SHBG (sex hormone-binding globulin).
In trials comparing different myo-inositol to d-chiro-inositol ratios, the 40:1 ratio — the same ratio used in Unwind — consistently performed best for ovulation and hormonal parameters. In one randomized clinical trial, 86% of participants taking d-chiro-inositol ovulated, compared to 27% on placebo.
Inositols function as intracellular messengers for insulin and reproductive hormones. When these signaling pathways improve, downstream hormone communication follows. Unwind pairs this metabolic foundation with nighttime nervous system support to balance stress and sleep shape hormone rhythm every single day.
02 CYCLE
CYCLE RHYTHM SUPPORT
A regular cycle is a sign of coordinated signaling between insulin, ovarian function, and FSH pathways. When one system is dysregulated, the others feel it.
What the research shows
Meta-analyses of myo-inositol and myo-inositol + d-chiro-inositol trials in women with PCOS report consistent improvements in menstrual regularity, ovulatory frequency, and hormonal markers tied to cycle stability. The 40:1 ratio is repeatedly referenced in research as the physiologic ratio found in healthy ovarian tissue.
Why it matters
Cycle rhythm depends on metabolic stability and coordinated ovarian signaling. Sleep and stress regulation further reinforce this rhythm over time, which is exactly why nighttime is where Unwind works.
03 • SLEEP
SLEEP QUALITY SUPPORT
Sleep isn’t passive recovery. It’s a regulatory window that influences cortisol rhythm, insulin sensitivity, and next-day hormone signaling. Protecting it matters more than most people realize.
Magnesium bisglycinate — In a randomized controlled trial in adults with poor sleep quality, magnesium bisglycinate reduced insomnia severity scores by approximately 28% over four weeks, compared to 18% in the placebo group.
GABA — In an EEG-measured, placebo-controlled crossover study, oral GABA shortened sleep latency and increased non-REM sleep time compared to placebo.
L-theanine — In stress challenge trials, L-theanine increased alpha brain wave activity — the state associated with calm, relaxed wakefulness — without sedation.
Better sleep supports metabolic regulation and cortisol rhythm. Sleep and hormone signaling are directly connected. Unwind is designed for the hours when that connection is most active.
04 • Stress
STRESS RESPONSE & CORTISOL RHYTHM SUPPORT
Cortisol follows a natural daily rhythm, rising in the morning, falling at night. Chronic stress disrupts that pattern. And when it does, sleep and insulin sensitivity are among the first things to suffer.
In a randomized, triple-blind, placebo-controlled crossover trial using an acute stress challenge, L-theanine significantly reduced salivary cortisol, lowered subjective anxiety, and improved physiological stress markers compared to placebo.
Chronic elevated cortisol is associated with impaired insulin sensitivity and disrupted hormone communication. Supporting nighttime calm isn’t just nice-to-have; it helps reinforce the rhythm that metabolism and hormones rely on to do their job.
05 • Metabolism
INSULIN RESISTANCE & BLOOD SUGAR SUPPORT
A 2025 systematic review and meta-analysis estimated that insulin resistance affects 27.67% of women globally. Or more than 1 in 4 women may be living with insulin resistance.
Inositol supplementation has been consistently associated with reductions in fasting insulin and insulin resistance (HOMA-IR), improvements in triglycerides, and broader metabolic stabilization. Research also links chronic stress and elevated cortisol to reduced insulin sensitivity, meaning the stress pathway and the metabolic pathway aren’t separate problems.
Unwind supports insulin signaling through inositols, stress signaling through L-theanine, and sleep quality through magnesium and GABA. Metabolism doesn’t operate independently from stress and sleep. Unwind doesn’t either.
06 Skin
CLEARER-LOOKING SKIN SUPPORT
Skin clarity is more metabolic than most skincare conversation lets on. Insulin signaling and androgen pathways have a direct relationship with what shows up on your face.
What the research shows
Clinical research in women with PCOS reports improvements in acne severity following longer-term myo-inositol supplementation. Meta-analyses show strong associations between insulin resistance and acne severity.
Why it matters
When insulin signaling and androgen-related pathways stabilize, skin clarity often follows over time, not overnight. Supporting metabolic and stress pathways leads to more than one visible outcome.
07 • Ovulation
OVULATION SUPPORT
Ovulation is one of the clearest signals that hormone rhythm is working. When it’s irregular or absent, it’s often a sign that something upstream in the metabolic or hormonal system needs support.
In a randomized clinical trial, 86% of participants taking d-chiro-inositol ovulated compared to 27% on placebo. In 40:1 ratio trials, ovulation outcomes were stronger than in other tested ratios.
Ovulation depends on coordinated metabolic, ovarian, and hormonal signaling. By supporting the broader system, you strengthen this outcome.
08 Mood
CALM MOOD & NEXT-DAY STEADINESS SUPPORT
How you feel in the morning is largely a product of what happened the night before — how well you slept, how your nervous system recovered, how your cortisol rhythm held.
What the research shows
L-theanine reduced salivary cortisol in controlled stress trials. Magnesium bisglycinate improved insomnia severity scores in randomized trials. And, improved sleep quality is consistently associated with better mood steadiness and cognitive function in sleep research.
Why it matters
When sleep improves and stress signaling settles, mornings feel less reactive. Regulation compounds. That’s the point.